Bristol Myers Squibb is committed to helping appropriate patients get access to our
medications by providing access and reimbursement support services.

This information is intended for U.S. healthcare professionals and/or healthcare professionals involved in healthcare reimbursement.

Billing and
Diagnosis Codes

Unresectable or Metastatic Melanoma (mMelanoma) and Adjuvant Treatment of Melanoma (Adj Tx of Melanoma) Monotherapy

The accurate completion of reimbursement- or coverage-related documentation is the responsibility of the healthcare provider and patient. Bristol Myers Squibb and its agents make no guarantee regarding reimbursement for any service or item.

Reimbursement and Coding Guide for OPDIVO
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Type a keyword to find a specific HCPCS, CPT, NDC, or ICD-10 code
Healthcare Common Procedure Coding System (HCPCS) Codes1 Issued by CMS
J9299

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Injection, nivolumab, 1 mg

Providers and suppliers are required to report the JW modifier on Part B drug claims for discarded drugs and biologicals. Also, providers and suppliers must document the amount of discarded drugs or biologicals in Medicare beneficiaries’ medical records.2

Revenue Codes (for Use in the Hospital Outpatient Setting)3
0636

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Drugs requiring detailed coding

0335

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Chemotherapy administration, IV

0260

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IV Therapy-General

Current Procedural Terminology (CPT)4,†
96413

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Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug

National Drug Codes (NDC)5 Issued by the FDA

Note:Payers require the submission of the 11-digit NDC on healthcare claim forms. Please use the 11-digit codes shown here.

00003-3772-11

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40 mg/4 mL (10 mg/mL) single-dose vial

00003-3774-12

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100 mg/10 mL (10 mg/mL) single-dose vial

00003-3734-13

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240 mg/24 mL (10 mg/mL) single-dose vial

International Classification of Diseases, Tenth Revision, Clinical Modification Diagnosis Codes (ICD-10-CM)6
C43

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Malignant melanoma of skin

C43.0

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Malignant melanoma of lip

C43.1

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Malignant melanoma of eyelid, including canthus

C43.10

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Malignant melanoma of unspecified eyelid, including canthus

C43.11

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Malignant melanoma of right eyelid, including canthus

C43.111

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Malignant melanoma of right upper eyelid, including canthus

C43.112

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Malignant melanoma of right lower eyelid, including canthus

C43.12

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Malignant melanoma of left eyelid, including canthus

C43.121

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Malignant melanoma of left upper eyelid, including canthus

C43.122

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Malignant melanoma of left lower eyelid, including canthus

C43.2

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Malignant melanoma of ear and external auricular canal

C43.20

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Malignant melanoma of unspecified ear and external auricular canal

C43.21

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Malignant melanoma of right ear and external auricular canal

C43.22

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Malignant melanoma of left ear and external auricular canal

C43.3

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Malignant melanoma of other and unspecified parts of face

C43.30

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Malignant melanoma of unspecified part of face

C43.31

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Malignant melanoma of nose

C43.39

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Malignant melanoma of other parts of face

C43.4

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Malignant melanoma of scalp and neck

C43.5

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Malignant melanoma of trunk

C43.51

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Malignant melanoma of anal skin

C43.52

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Malignant melanoma of skin of breast

C43.59

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Malignant melanoma of other part of trunk

C43.6

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Malignant melanoma of upper limb, including shoulder

C43.60

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Malignant melanoma of unspecified upper limb, including shoulder

C43.61

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Malignant melanoma of right upper limb, including shoulder

C43.62

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Malignant melanoma of left upper limb, including shoulder

C43.7

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Malignant melanoma of lower limb, including hip

C43.70

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Malignant melanoma of unspecified lower limb, including hip

C43.71

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Malignant melanoma of right lower limb, including hip

C43.72

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Malignant melanoma of left lower limb, including hip

C43.8

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Malignant melanoma of overlapping sites of skin

C43.9

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Malignant melanoma of skin, unspecified

C21

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Malignant neoplasm of anus and anal canal

C21.0

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Malignant neoplasm of anus, unspecified

C21.1

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Malignant neoplasm of anal canal

C51

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Malignant neoplasm of vulva

C51.0

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Malignant neoplasm of labium majus

C51.1

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Malignant neoplasm of labium minus

C51.2

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Malignant neoplasm of clitoris

C51.9

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Malignant neoplasm of vulva, unspecified

C52

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Malignant neoplasm of vagina

C57

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Malignant neoplasm of other and unspecified female genital organs

C57.7

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Malignant neoplasm of other specified female genital organs

C57.8

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Malignant neoplasm of overlapping sites of female genital organs

C57.9

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Malignant neoplasm of female genital organ, unspecified

C60

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Malignant neoplasm of penis

C60.0

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Malignant neoplasm of prepuce

C60.1

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Malignant neoplasm of glans penis

C60.8

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Malignant neoplasm of overlapping sites of penis

C60.9

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Malignant neoplasm of penis, unspecified

C63

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Malignant neoplasm of other and unspecified male genital organs

C63.0

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Malignant neoplasm of epididymis

C63.00

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Malignant neoplasm of unspecified epididymis

C63.01

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Malignant neoplasm of right epididymis

C63.02

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Malignant neoplasm of left epididymis

C63.1

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Malignant neoplasm of spermatic cord

C63.10

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Malignant neoplasm of unspecified spermatic cord

C63.11

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Malignant neoplasm of right spermatic cord

C63.12

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Malignant neoplasm of left spermatic cord

C63.2

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Malignant neoplasm of scrotum

C63.7

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Malignant neoplasm of other specified male genital organs

C63.8

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Malignant neoplasm of overlapping sites of male genital organs

C63.9

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Malignant neoplasm of male genital organ, unspecified

Z51.12   

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Encounter for antineoplastic immunotherapy 

If infusion for antineoplastic immunotherapy is the only reason for the patient encounter, physicians and hospitals may report ICD-10-CM code “Z51.12 Encounter for antineoplastic immunotherapy” as the primary diagnosis.

OPDIVO may be purchased through the distributors listed below.

Physician Offices

Specialty Distributor Phone Orders Website
Cardinal Health Specialty Pharmaceutical Distribution 1-877-453-3972
Monday-Friday,
7 AM-6 PM CT
(24-hour emergency on call)
https://specialty
online.cardinal
health.com
CuraScript Specialty Distribution 1-866-433-3589
Monday-Friday,
8 AM-7 PM ET
https://www.
curascriptsd.
com
McKesson Specialty Health 1-800-482-6700
Monday-Friday,
7 AM-7 PM CT
https://mscs.
mckesson.com
Oncology Supply 1-800-633-7555
Monday-Friday,
8 AM-7 PM CT
https://www.
oncologysupply.
com

For offices that prefer to use the services of a specialty pharmacy, specialty pharmacies can obtain OPDIVO from the distributors listed above.

Hospitals and Infusion Centers

Specialty Distributor Phone Orders Fax Orders and Website
ASD Healthcare 1-800-746-6273 Monday-Thursday,
7 AM-6:30 PM CT; Friday,
7 AM-6 PM CT
(24-hour emergency on call)
1-800-547-9413
https://www.
asdhealthcare.
com
Cardinal Health Specialty Pharmaceutical Distribution 1-866-677-4844 Monday-Friday,
7 AM-6 PM CT
(24-hour emergency on call)
1-614-553-6301
https://order
express.cardinal
health.com
DMS Pharmaceutical Group, Inc. 1-877-788-1100
Monday-Friday,
8:30 AM-5 PM CT
1-847-518-1105
www.dms
pharma.com
McKesson Plasma and Biologics 1-877-625-2566
Monday-Friday,
8 AM-6:30 PM CT
1-888-752-7626
https://connect.
mckesson.com
Smith Medical Partners 1-800-292-9653
Monday-Thursday,
8 AM-6 PM CT;
Friday, 8 AM-4:30 PM CT
1-630-227-9220
www.smp
specialty.com

Above information is accurate as of 07/20.

The OPDIVO distribution program includes extended payment terms to Bristol Myers Squibb authorized OPDIVO distributors. Healthcare providers and institutions should contact their OPDIVO distributor to understand specific payment terms that may be available to them from their distributor.

Please see U.S. Full Prescribing Information for OPDIVO.

Unresectable or Metastatic Melanoma

FDA Approval Letters as Posted by the FDA:

OPDIVO for the treatment of patients with unresectable or metastatic melanoma (indication simplification) - Approved on 03/07/2019

View Letter

OPDIVO for the treatment of patients with BRAF V600 mutation positive, unresectable or metastatic melanoma (restriction removal that patients should have disease progression following ipilimumab and a BRAF inhibitor) - Approved on 01/23/2016

View Letter

OPDIVO for the treatment of patients with BRAF wild-type unresectable or metastatic melanoma - Approved on 11/23/2015

View Letter

OPDIVO for the treatment of unresectable or metastatic melanoma and disease progression following ipilimumab and, if BRAF V600 mutation positive, a BRAF inhibitor- Approved 12/22/2014

View Letter

Flat Dosing for OPDIVO (240 mg every 2 weeks) - Approved on 09/13/2016

View Letter

Flat Dosing for OPDIVO (480 mg every 4 weeks) - Approved on 03/05/2018

View Letter

Adjuvant Treatment of Melanoma

FDA Approval Letters as Posted by the FDA:

OPDIVO for the adjuvant treatment of patients with melanoma with involvement of lymph nodes or metastatic disease who have undergone complete resection - Approved on 12/20/2017

View Letter

Flat Dosing for OPDIVO (240 mg every 2 weeks, or 480 mg every 4 weeks) - Approved on 03/05/2018

View Letter

Please see U.S. Full Prescribing Information for OPDIVO and YERVOY® (ipilimumab) for complete indications.

Coding for OPDIVO is dependent on the insurer and the care setting in which the drug will be administered. Oncology practices need to make coding decisions based on the diagnosis and treatment of each patient and the specific insurer requirements.

Please see U.S. Full Prescribing Information for OPDIVO.

*Healthcare providers should code healthcare claims based upon the service that is rendered, the patient's medical record, the coding requirements of each health insurer, and best coding practices. Coding information provided under this heading does not provide a guarantee of reimbursement and should be considered together with all applicable coding guidance and standards. All of the coding information presented by this website is applicable to outpatient procedures only.

†CPT codes and descriptions only are ©2019 by American Medical Association (AMA). All rights reserved. The AMA assumes no liability for data contained or not contained herein. CPT is a registered trademark of the American Medical Association.

References:

  1. American Medical Association. 2020 HCPCS Level II. Professional ed. Chicago, IL: American Medical Association; 2020.
  2. Centers for Medicare & Medicaid Services. MLN Matters, Number MM9603 Revised. https://www.cms.gov/Outreach-and-Education/Medicare-Learning-Network-MLN/MLNMattersArticles/Downloads/MM9603.pdf. Revised June 10, 2016. Accessed November 15, 2019.
  3. Palmetto GBA. Medicare Part A Billing Guide. May 2017. http://www.palmettogba.com/Palmetto/Providers.Nsf/files/ Part_A_Billing_Guide.pdf/$File/Part_A_Billing_Guide.pdf. Accessed October 10, 2019.
  4. American Medical Association. CPT Professional 2020. Professional ed. Chicago, IL: American Medical Association; 2019.
  5. OPDIVO [package insert]. Princeton, NJ: Bristol-Myers Squibb Company.
  6. American Medical Association. 2020 ICD-10-CM: The Complete Official Codebook. Chicago, IL: American Medical Association; 2019.

The accurate completion of reimbursement- or coverage-related documentation is the responsibility of the healthcare provider and patient. Bristol Myers Squibb and its agents make no guarantee regarding reimbursement for any service or item.

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Use of the information on this site is subject to the terms of our Legal Notice and Privacy Statement. The coding, coverage, and payment information contained within this website is current as of 07/20.

1506US2001674-01-01 07/20